Pd-catalyzed enantiodivergent and regiospecific phospha-michael addition of diphenylphosphine to 4-oxo-enamides : efficient access to chiral phosphinocarboxamides and their analogues

The palladacycle-catalyzed asymmetric P-H addition of 4-oxo-enamides has been developed, which provides efficient access to phosphinocarboxamides and their analogues. Solvent-mediated reversal of stereoselectivity (ee from +96 % to −92 %) was observed, and the underlying mechanism that allows facile...

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Bibliographic Details
Main Authors: Chew, Renta Jonathan, Li, Xi-Rui, Li, Yongxin, Pullarkat, Appukuttan Sumod, Leung, Pak-Hing
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2015
Subjects:
Online Access:https://hdl.handle.net/10356/106877
http://hdl.handle.net/10220/25190
http://dx.doi.org/10.1002/chem.201406298
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Institution: Nanyang Technological University
Language: English