Modulation of Huh7.5 spheroid formation and functionality using modified PEG-based hydrogels of different stiffness

• Main Authors: Lee, Bae Hoon, Kim, Myung Hee, Lee, Jae Ho, Seliktar, Dror, Cho, Nam-Joon, Tan, Lay Poh
• Other Authors: Zhu, Donghui
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Engineering::Materials::Mechanical strength of materials
• Online Access: https://hdl.handle.net/10356/106903; http://hdl.handle.net/10220/25243
• Institution: Nanyang Technological University

Physical cues, such as cell microenvironment stiffness, are known to be important factors in modulating cellular behaviors such as differentiation, viability, and proliferation. Apart from being able to trigger these effects, mechanical stiffness tuning is a very convenient approach that could be im...