Mechanism of stapled peptide binding to MDM2 : possible consequences for peptide design

• Main Authors: Sim, Adelene Y. L., Joseph, Thomas, Lane, David P., Verma, Chandra
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Biochemistry
• Online Access: https://hdl.handle.net/10356/106916; http://hdl.handle.net/10220/25194
• Institution: Nanyang Technological University

MDM2 is a negative regulator of p53. The N terminal domain of MDM2 interacts with a helical region of the transcriptional activation domain of p53. Stapled peptides have been designed to mimic this interaction, in order to inhibit p53-MDM2 binding and thereby activate the p53 response. Here, we stud...