Rational optimization of conformational effects induced by hydrocarbon staples in peptides and their binding interfaces
eIF4E is frequently over-expressed in different cancers and causes increased translation of oncogenic proteins via deregulated cap-dependent translation. Inhibitors of the eIF4E:eIF4G interactions represent an approach that would normalize cap-dependent translation. Stapled peptides represent an eme...
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| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/101384 http://hdl.handle.net/10220/18637 |
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| Institution: | Nanyang Technological University |
| Language: | English |