Rational optimization of conformational effects induced by hydrocarbon staples in peptides and their binding interfaces

• Main Authors: Lama, Dilraj, Lakshminarayanan, Rajamani, Lane, David P., Brown, Christopher J., Quah, Soo T., Verma, Chandra S., Beuerman, Roger W.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/101384; http://hdl.handle.net/10220/18637
• Institution: Nanyang Technological University

eIF4E is frequently over-expressed in different cancers and causes increased translation of oncogenic proteins via deregulated cap-dependent translation. Inhibitors of the eIF4E:eIF4G interactions represent an approach that would normalize cap-dependent translation. Stapled peptides represent an eme...