Protein arginine methyltransferase 6 enhances ligand-dependent and -independent activity of estrogen receptor α via distinct mechanisms

• Main Authors: Sun, Yang, Chung, Hwa Hwa, Woo, Amanda Rui En, Lin, Valerie C.-L.
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2015
• 主題: DRNTU::Science::Biological sciences::Molecular biology
• 在線閱讀: https://hdl.handle.net/10356/106919; http://hdl.handle.net/10220/25191
• 機構: Nanyang Technological University

Recent studies reported that protein arginine methyltransferase 6 (PRMT6) enhances estrogen-induced activity of estrogen receptor α (ERα) and dysfunction of PRMT6 is associated with overall better survival for ERα-positive breast cancer patients. However, it is unclear how PRMT6 promotes ERα activit...