Crystal structure of Gib2, a signal-transducing protein scaffold associated with ribosomes in cryptococcus neoformans

• Main Authors: Ero, Rya, Dimitrova, Valya Tenusheva, Chen, Yun, Bu, Wenting, Feng, Shu, Liu, Tongbao, Wang, Ping, Xue, Chaoyang, Tan, Suet Mien, Gao, Yong-Gui
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/106985; http://hdl.handle.net/10220/25268
• Institution: Nanyang Technological University

The atypical Gβ-like/RACK1 Gib2 protein promotes cAMP signalling that plays a central role in regulating the virulence of Cryptococcus neoformans. Gib2 contains a seven-bladed β transducin structure and is emerging as a scaffold protein interconnecting signalling pathways through interactions with v...