Tuning drug release in polyester thin films : terminal end-groups determine specific rates of additive-free controlled drug release

Modulating the drug release from polyester matrices independently of material properties would be beneficial to those designing biodegradable medical implants, such as drug delivery devices, stents and screws. However, the most common approaches use additives that often drastically alter the desired...

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Main Authors: Steele, Terry W. J., Huang, Charlotte Liwen, Kumar, Saranya, Iskandar, Aneesa, Baoxin, Aw, Boey, Freddy Yin Chiang, Loo, Say Chye Joachim, Venkatraman, Subbu S.
Other Authors: School of Materials Science & Engineering
Format: Article
Language:English
Published: 2013
Online Access:https://hdl.handle.net/10356/107001
http://hdl.handle.net/10220/17865
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1070012023-07-14T15:54:23Z Tuning drug release in polyester thin films : terminal end-groups determine specific rates of additive-free controlled drug release Steele, Terry W. J. Huang, Charlotte Liwen Kumar, Saranya Iskandar, Aneesa Baoxin, Aw Boey, Freddy Yin Chiang Loo, Say Chye Joachim Venkatraman, Subbu S. School of Materials Science & Engineering Modulating the drug release from polyester matrices independently of material properties would be beneficial to those designing biodegradable medical implants, such as drug delivery devices, stents and screws. However, the most common approaches use additives that often drastically alter the desired material properties. Recently, we have developed tools that allow gradient film formulations and high-throughput drug quantitation for the determination of parameter-specific correlations. We propose that modulated drug release can be obtained via additive-free mechanisms in polyesters by simply controlling polymer erosion through acidic terminal functional groups. Our results showed that drug release in poly(lactic-co-glycolic acid) (PLGA) formulations could be tuned to produce large ranges in drug release with relatively small changes in terminal acidic functional groups. For example, PLGA 53/47 thin films could be tuned to have 10–60% drug release at 14 days or 10–90% drug release at 20 days, depending on the PLGA/PLGA blend formulation and concentration of acidic terminal functional groups. A linear R-square correlation of up to 0.9 was observed for the acidic groups and percent drug release. Below a threshold of 1 part per thousand acidic groups, there was no increase in drug release, which has implications for polymer processing and film integrity. Published Version 2013-11-27T05:11:11Z 2019-12-06T22:22:50Z 2013-11-27T05:11:11Z 2019-12-06T22:22:50Z 2013 2013 Journal Article Steele, T. W. J., Huang, C. L., Kumar, S., Iskandar, A., Baoxin, A., Boey, F. Y. C., Loo, S. C. J., & Venkatraman, S. S. (2013). Tuning drug release in polyester thin films: terminal end-groups determine specific rates of additive-free controlled drug release. NPG Asia materials, 5(4), e46-. 1884-4057 https://hdl.handle.net/10356/107001 http://hdl.handle.net/10220/17865 10.1038/am.2013.9 en NPG Asia materials © 2013 Nature Japan K.K. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
description Modulating the drug release from polyester matrices independently of material properties would be beneficial to those designing biodegradable medical implants, such as drug delivery devices, stents and screws. However, the most common approaches use additives that often drastically alter the desired material properties. Recently, we have developed tools that allow gradient film formulations and high-throughput drug quantitation for the determination of parameter-specific correlations. We propose that modulated drug release can be obtained via additive-free mechanisms in polyesters by simply controlling polymer erosion through acidic terminal functional groups. Our results showed that drug release in poly(lactic-co-glycolic acid) (PLGA) formulations could be tuned to produce large ranges in drug release with relatively small changes in terminal acidic functional groups. For example, PLGA 53/47 thin films could be tuned to have 10–60% drug release at 14 days or 10–90% drug release at 20 days, depending on the PLGA/PLGA blend formulation and concentration of acidic terminal functional groups. A linear R-square correlation of up to 0.9 was observed for the acidic groups and percent drug release. Below a threshold of 1 part per thousand acidic groups, there was no increase in drug release, which has implications for polymer processing and film integrity.
author2 School of Materials Science & Engineering
author_facet School of Materials Science & Engineering
Steele, Terry W. J.
Huang, Charlotte Liwen
Kumar, Saranya
Iskandar, Aneesa
Baoxin, Aw
Boey, Freddy Yin Chiang
Loo, Say Chye Joachim
Venkatraman, Subbu S.
format Article
author Steele, Terry W. J.
Huang, Charlotte Liwen
Kumar, Saranya
Iskandar, Aneesa
Baoxin, Aw
Boey, Freddy Yin Chiang
Loo, Say Chye Joachim
Venkatraman, Subbu S.
spellingShingle Steele, Terry W. J.
Huang, Charlotte Liwen
Kumar, Saranya
Iskandar, Aneesa
Baoxin, Aw
Boey, Freddy Yin Chiang
Loo, Say Chye Joachim
Venkatraman, Subbu S.
Tuning drug release in polyester thin films : terminal end-groups determine specific rates of additive-free controlled drug release
author_sort Steele, Terry W. J.
title Tuning drug release in polyester thin films : terminal end-groups determine specific rates of additive-free controlled drug release
title_short Tuning drug release in polyester thin films : terminal end-groups determine specific rates of additive-free controlled drug release
title_full Tuning drug release in polyester thin films : terminal end-groups determine specific rates of additive-free controlled drug release
title_fullStr Tuning drug release in polyester thin films : terminal end-groups determine specific rates of additive-free controlled drug release
title_full_unstemmed Tuning drug release in polyester thin films : terminal end-groups determine specific rates of additive-free controlled drug release
title_sort tuning drug release in polyester thin films : terminal end-groups determine specific rates of additive-free controlled drug release
publishDate 2013
url https://hdl.handle.net/10356/107001
http://hdl.handle.net/10220/17865
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