Structure of a left-handed DNA G-quadruplex

• المؤلفون الرئيسيون: Chung, Wan Jun, Heddi, Brahim, Schmitt, Emmanuelle, Lim, Kah Wai, Mechulam, Yves, Phan, Anh Tuân
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2015
• الموضوعات: G-quadruplex; left-handed helix; nucleic acid; NMR; X-ray crystallography
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/107059; http://hdl.handle.net/10220/25356

Aside from the well-known double helix, DNA can also adopt an alternative four-stranded structure known as G-quadruplex. Implications of such a structure in cellular processes, as well as its therapeutic and diagnostic applications, have been reported. The G-quadruplex structure is highly polymorphi...