The systemic lupus erythematosus–associated single nucleotide polymorphism rs1143678 in integrin αM cytoplasmic tail generates a 14-3-3ζ binding site that is proinflammatory
The leukocyte integrin αMβ2 (CR3 or Mac-1) has both proinflammatory and immune regulatory functions. Genome-wide association studies have identified several ITGAM (αM subunit) single nucleotide polymorphisms that are associated with systemic lupus erythematosus. The single nucleotide polymorphism rs...
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Main Authors: | Ong, Li-Teng, Tan, Hui-Foon, Feng, Chen, Qu, Jing, Loh, Shuzk-Cheng, Bhattacharyya, Surajit, Tan, Suet-Mien |
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Other Authors: | School of Biological Sciences |
Format: | Article |
Language: | English |
Published: |
2019
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/107073 http://hdl.handle.net/10220/49045 http://dx.doi.org/10.4049/jimmunol.1601447 |
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Institution: | Nanyang Technological University |
Language: | English |
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