The systemic lupus erythematosus–associated single nucleotide polymorphism rs1143678 in integrin αM cytoplasmic tail generates a 14-3-3ζ binding site that is proinflammatory

• Main Authors: Ong, Li-Teng, Tan, Hui-Foon, Feng, Chen, Qu, Jing, Loh, Shuzk-Cheng, Bhattacharyya, Surajit, Tan, Suet-Mien
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Systemic Lupus Erythematosus; Single Nucleotide Polymorphism; Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/107073; http://hdl.handle.net/10220/49045; http://dx.doi.org/10.4049/jimmunol.1601447
• Institution: Nanyang Technological University

The leukocyte integrin αMβ2 (CR3 or Mac-1) has both proinflammatory and immune regulatory functions. Genome-wide association studies have identified several ITGAM (αM subunit) single nucleotide polymorphisms that are associated with systemic lupus erythematosus. The single nucleotide polymorphism rs...