Intracellular reduction-responsive sheddable copolymer micelles for targeted anticancer drug delivery
Intracellular, reduction-responsive, amphiphilic, copolymer micelles with cancer cell specificity were developed. The copolymer was prepared with controlled molecular weight and functionalities using a double-headed initiator consisting of a disulfide linkage and folic acid targeting unit. The polym...
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sg-ntu-dr.10356-1070742020-06-01T10:13:48Z Intracellular reduction-responsive sheddable copolymer micelles for targeted anticancer drug delivery Zhao, Yanli Zhang, Yuanyuan Qu, Qiuyu Li, Menghuan School of Materials Science & Engineering School of Physical and Mathematical Sciences DRNTU::Science::Chemistry::Organic chemistry Intracellular, reduction-responsive, amphiphilic, copolymer micelles with cancer cell specificity were developed. The copolymer was prepared with controlled molecular weight and functionalities using a double-headed initiator consisting of a disulfide linkage and folic acid targeting unit. The polymer could self-assemble into spherical micelles, which were stable under physiological conditions. Anticancer drug doxorubicin (DOX) was encapsulated into the micelles during the micellization and then released rapidly into the environment under the stimulus of intracellular reducing agent glutathione. Flow cytometry and confocal laser scanning microscopy observations further indicated that DOX was successfully released from the internalized micelles into the cytoplasm, inducing apoptosis and cell death. The potential of the present copolymer micelles for application as anticancer drug carriers for targeted cancer therapy is promising. 2015-03-24T07:57:42Z 2019-12-06T22:24:13Z 2015-03-24T07:57:42Z 2019-12-06T22:24:13Z 2015 2015 Journal Article Zhang, Y., Qu, Q., Li, M., & Zhao, Y. (2015). Intracellular reduction-responsive sheddable copolymer micelles for targeted anticancer drug delivery. Asian Journal of organic chemistry, 4(3), 226-232. 2193-5807 https://hdl.handle.net/10356/107074 http://hdl.handle.net/10220/25270 10.1002/ajoc.201402146 en Asian journal of organic chemistry © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
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DRNTU::Science::Chemistry::Organic chemistry Zhao, Yanli Zhang, Yuanyuan Qu, Qiuyu Li, Menghuan Intracellular reduction-responsive sheddable copolymer micelles for targeted anticancer drug delivery |
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Intracellular, reduction-responsive, amphiphilic, copolymer micelles with cancer cell specificity were developed. The copolymer was prepared with controlled molecular weight and functionalities using a double-headed initiator consisting of a disulfide linkage and folic acid targeting unit. The polymer could self-assemble into spherical micelles, which were stable under physiological conditions. Anticancer drug doxorubicin (DOX) was encapsulated into the micelles during the micellization and then released rapidly into the environment under the stimulus of intracellular reducing agent glutathione. Flow cytometry and confocal laser scanning microscopy observations further indicated that DOX was successfully released from the internalized micelles into the cytoplasm, inducing apoptosis and cell death. The potential of the present copolymer micelles for application as anticancer drug carriers for targeted cancer therapy is promising. |
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School of Materials Science & Engineering |
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School of Materials Science & Engineering Zhao, Yanli Zhang, Yuanyuan Qu, Qiuyu Li, Menghuan |
format |
Article |
author |
Zhao, Yanli Zhang, Yuanyuan Qu, Qiuyu Li, Menghuan |
author_sort |
Zhao, Yanli |
title |
Intracellular reduction-responsive sheddable copolymer micelles for targeted anticancer drug delivery |
title_short |
Intracellular reduction-responsive sheddable copolymer micelles for targeted anticancer drug delivery |
title_full |
Intracellular reduction-responsive sheddable copolymer micelles for targeted anticancer drug delivery |
title_fullStr |
Intracellular reduction-responsive sheddable copolymer micelles for targeted anticancer drug delivery |
title_full_unstemmed |
Intracellular reduction-responsive sheddable copolymer micelles for targeted anticancer drug delivery |
title_sort |
intracellular reduction-responsive sheddable copolymer micelles for targeted anticancer drug delivery |
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2015 |
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https://hdl.handle.net/10356/107074 http://hdl.handle.net/10220/25270 |
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1681058487901093888 |