Crystallization and preliminary crystallographic analysis of human aquaporin 1 at a resolution of 3.28 Å

• Main Authors: Torres, Jaume, Ruiz Carrillo, David, To Yiu Ying, Janet, Darwis, Dina, Soon, Cin Huang, Cornvik, Tobias, Lescar, Julien
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Bacteria
• Online Access: https://hdl.handle.net/10356/107181; http://hdl.handle.net/10220/25416
• Institution: Nanyang Technological University

Aquaporin water channels (AQPs) are found in almost every organism from humans to bacteria. In humans, 13 classes of AQPs control water and glycerol homeostasis. Knockout studies have suggested that modulating the activity of AQPs could be beneficial for the treatment of several pathologies. In part...