MicroRNAs as therapeutic strategy for hepatitis B virus-associated hepatocellular carcinoma : current status and future prospects

Hepatocellular carcinoma (HCC) remains to be one of the top causing cancer-related deaths today. The majority of HCC cases are reported to be the result of chronic hepatitis B virus (HBV) infection. Current treatments for HBV-related HCC revolve around the use of drugs to inhibit viral replication,...

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Main Authors: Tan, Yi Lin Jane, Chen, Wei Ning
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2015
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Online Access:https://hdl.handle.net/10356/107199
http://hdl.handle.net/10220/25366
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Institution: Nanyang Technological University
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spelling sg-ntu-dr.10356-1071992023-12-29T06:49:06Z MicroRNAs as therapeutic strategy for hepatitis B virus-associated hepatocellular carcinoma : current status and future prospects Tan, Yi Lin Jane Chen, Wei Ning School of Chemical and Biomedical Engineering DRNTU::Science::Biological sciences::Human anatomy and physiology Hepatocellular carcinoma (HCC) remains to be one of the top causing cancer-related deaths today. The majority of HCC cases are reported to be the result of chronic hepatitis B virus (HBV) infection. Current treatments for HBV-related HCC revolve around the use of drugs to inhibit viral replication, as a high level of viral load and antigen in circulation often presents a poor patient prognosis. However, existing therapies are inefficient in the complete eradication of HBV, often resulting in tumour recurrence. The involvement of microRNAs (miRNAs) in important processes in HBV-related HCC makes it an important player in the progression of HCC in chronic hepatitis B infected patients. In this review, we discuss the key aspects of HBV infection and the important viral products that may regulate cancer-related processes via their interaction with miRNAs or their closely related protein machinery. Conversely, we also look at how miRNAs may go about regulating the virus, especially in vital processes like viral replication. Apart from miRNAs acting as either oncogenes or tumour-suppressors, we also look at how miRNAs may function as biomarkers that may possibly serve as better candidates than those currently employed in the diagnosis of HBV infection or HBV-related HCC. A summary of the roles of miRNAs in HBV-related HCC will hopefully lead to a gain in understanding of the pathogenesis process and pave the way for new insights in medical therapy. Published version 2015-04-10T08:15:10Z 2019-12-06T22:26:33Z 2015-04-10T08:15:10Z 2019-12-06T22:26:33Z 2014 2014 Journal Article Tan, Y. L. J., & Chen, W. N. (2014). MicroRNAs as therapeutic strategy for hepatitis B virus-associated hepatocellular carcinoma : current status and future prospects. World journal of gastroenterology, 20(20), 5973-5986. 1007-9327 https://hdl.handle.net/10356/107199 http://hdl.handle.net/10220/25366 10.3748/wjg.v20.i20.5973 24876720 en World journal of gastroenterology © 2014 Baishideng Publishing. This paper was published in World Journal of Gastroenterology and is made available as an electronic reprint (preprint) with permission of Baishideng Publishing. The paper can be found at the following official DOI: [http://dx.doi.org/10.3748/wjg.v20.i20.5973].  One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Biological sciences::Human anatomy and physiology
spellingShingle DRNTU::Science::Biological sciences::Human anatomy and physiology
Tan, Yi Lin Jane
Chen, Wei Ning
MicroRNAs as therapeutic strategy for hepatitis B virus-associated hepatocellular carcinoma : current status and future prospects
description Hepatocellular carcinoma (HCC) remains to be one of the top causing cancer-related deaths today. The majority of HCC cases are reported to be the result of chronic hepatitis B virus (HBV) infection. Current treatments for HBV-related HCC revolve around the use of drugs to inhibit viral replication, as a high level of viral load and antigen in circulation often presents a poor patient prognosis. However, existing therapies are inefficient in the complete eradication of HBV, often resulting in tumour recurrence. The involvement of microRNAs (miRNAs) in important processes in HBV-related HCC makes it an important player in the progression of HCC in chronic hepatitis B infected patients. In this review, we discuss the key aspects of HBV infection and the important viral products that may regulate cancer-related processes via their interaction with miRNAs or their closely related protein machinery. Conversely, we also look at how miRNAs may go about regulating the virus, especially in vital processes like viral replication. Apart from miRNAs acting as either oncogenes or tumour-suppressors, we also look at how miRNAs may function as biomarkers that may possibly serve as better candidates than those currently employed in the diagnosis of HBV infection or HBV-related HCC. A summary of the roles of miRNAs in HBV-related HCC will hopefully lead to a gain in understanding of the pathogenesis process and pave the way for new insights in medical therapy.
author2 School of Chemical and Biomedical Engineering
author_facet School of Chemical and Biomedical Engineering
Tan, Yi Lin Jane
Chen, Wei Ning
format Article
author Tan, Yi Lin Jane
Chen, Wei Ning
author_sort Tan, Yi Lin Jane
title MicroRNAs as therapeutic strategy for hepatitis B virus-associated hepatocellular carcinoma : current status and future prospects
title_short MicroRNAs as therapeutic strategy for hepatitis B virus-associated hepatocellular carcinoma : current status and future prospects
title_full MicroRNAs as therapeutic strategy for hepatitis B virus-associated hepatocellular carcinoma : current status and future prospects
title_fullStr MicroRNAs as therapeutic strategy for hepatitis B virus-associated hepatocellular carcinoma : current status and future prospects
title_full_unstemmed MicroRNAs as therapeutic strategy for hepatitis B virus-associated hepatocellular carcinoma : current status and future prospects
title_sort micrornas as therapeutic strategy for hepatitis b virus-associated hepatocellular carcinoma : current status and future prospects
publishDate 2015
url https://hdl.handle.net/10356/107199
http://hdl.handle.net/10220/25366
_version_ 1787136604221997056