SF3B1 association with chromatin determines splicing outcomes

• Main Authors: Kfir, Nir, Lev-Maor, Galit, Glaich, Ohad, Alajem, Adi, Datta, Arnab, Sze, Siu K., Meshorer, Eran, Ast, Gil
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/107367; http://hdl.handle.net/10220/25580
• Institution: Nanyang Technological University

Much remains unknown concerning the mechanism by which the splicing machinery pinpoints short exons within intronic sequences and how splicing factors are directed to their pre-mRNA targets. One probable explanation lies in differences in chromatin organization between exons and introns. Proteomic,...