PI3K-C2α knockdown results in rerouting of insulin signaling and pancreatic beta cell proliferation

• Main Authors: Leibiger, Barbara, Moede, Tilo, Paschen, Meike, Yunn, Na-Oh, Lim, Jong Hoon, Ryu, Sung Ho, Pereira, Teresa, Berggren, Per-Olof, Leibiger, Ingo B.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2015
• Online Access: https://hdl.handle.net/10356/107553; http://hdl.handle.net/10220/38769
• Institution: Nanyang Technological University

Insulin resistance is a syndrome that affects multiple insulin target tissues, each having different biological functions regulated by insulin. A remaining question is to mechanistically explain how an insulin target cell/tissue can be insulin resistant in one biological function and insulin sensiti...