A structural and functional study on Cot (MAPKKK8)

Cot (cancer Osaka thyroid, also known as Tpl-2), a proto-oncogenic kinase, is a member of the MAPKKK family and plays a key role in the regulation of the immune response to pro-inflammatory stimuli such as LPS (lipopolysaccharide) and TNF- (tumor necrosis factor-). After LPS-stimulation, Cot activ...

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Bibliographic Details
Main Author: Wu, Binhui
Other Authors: Rupert Charles Wilmouth
Format: Theses and Dissertations
Language:English
Published: 2008
Subjects:
Online Access:https://hdl.handle.net/10356/13576
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Institution: Nanyang Technological University
Language: English