A study of the functional domains of the type I iterative polyketide synthase CalE8 in calicheamicin biosynthesis

Naturally occurring enediynes are potent antibiotics produced by soil and marine microorganisms. Their robust antitumor activities and unique mode of action make them a significant topic of study. The synthesis of the enediyne products is initiated by a type I iterative polyketide synthase (PKS). In...

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Bibliographic Details
Main Author: Murugan, Elavazhagan
Other Authors: Liang Zhao-Xun
Format: Theses and Dissertations
Language:English
Published: 2012
Subjects:
Online Access:https://hdl.handle.net/10356/50212
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Institution: Nanyang Technological University
Language: English