Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis

• Main Authors: Liew, Chong Wai, Nilsson, Martina, Chen, Ming Wei, Sun, Huihua, Cornvik, Tobias Carl, Liang, Zhao-Xun, Lescar, Julien
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/104167; http://hdl.handle.net/10220/16984
• Institution: Nanyang Technological University

Biosynthesis of the enediyne natural product dynemicin in Micromonospora chersina is initiated by DynE8, a highly reducing iterative type I polyketide synthase that assembles polyketide intermediates from the acetate units derived solely from malonyl-CoA. To understand the substrate specificity and...