Synthesis of (R)-Mellein by a partially reducing iterative polyketide synthase

Mellein and the related 3,4-dihydroisocoumarins are a family of natural products with interesting biological properties. The mechanisms of dihydroisocoumarin biosynthesis remain largely speculative today. Here we report the synthesis of mellein by a partially reducing iterative polyketide synthase (...

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Bibliographic Details
Main Authors: Sun, Huihua, Ho, Chun Loong, Ding, Feiqing, Soehano, Ishin, Liu, Xue-Wei, Liang, Zhao-Xun
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2013
Subjects:
Online Access:https://hdl.handle.net/10356/97615
http://hdl.handle.net/10220/11204
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Institution: Nanyang Technological University
Language: English