Synthesis of (R)-Mellein by a partially reducing iterative polyketide synthase

• المؤلفون الرئيسيون: Sun, Huihua, Ho, Chun Loong, Ding, Feiqing, Soehano, Ishin, Liu, Xue-Wei, Liang, Zhao-Xun
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2013
• الموضوعات: DRNTU::Science::Biological sciences
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/97615; http://hdl.handle.net/10220/11204

Mellein and the related 3,4-dihydroisocoumarins are a family of natural products with interesting biological properties. The mechanisms of dihydroisocoumarin biosynthesis remain largely speculative today. Here we report the synthesis of mellein by a partially reducing iterative polyketide synthase (...