Embedding a ruthenium-based structural mimic of the [Fe]-hydrogenase cofactor into papain

• Main Authors: Barik, Chandan Kr, Ganguly, Rakesh, Li, Yongxin, Przybylski, Cédric, Salmain, Michèle, Leong, Weng Kee
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Chemistry; Science::Chemistry::Inorganic chemistry; Ruthenium; [Fe]- Hydrogenase
• Online Access: https://hdl.handle.net/10356/136695
• Institution: Nanyang Technological University

We describe the synthesis of the ruthenacyclic carbamoyl complexes [Ru(2-NHC(O)C5H3NMe)(CO)2( o,o-Me2-C6H3S)(L)] (L = H2O or MeCN), which have a labile water or acetonitrile ligand at their sixth coordination sites. Steric bulk around the ruthenium center is essential in preventing isomerization and...