Clinical relevance of screening checklists for detecting cancer predisposition syndromes in Asian childhood tumours

• Main Authors: Chan, Sock Hoai, Chew, Winston, Nur Diana Binte Ishak, Lim, Weng Khong, Li, Shao-Tzu, Tan, Sheng Hui, Teo, Jing Xian, Shaw, Tarryn, Chang, Kenneth, Chen, Yong, Iyer, Prasad, Tan, Enrica Ee Kar, Seng, Michaela Su-Fern, Chan, Mei Yoke, Tan, Ah Moy, Low, Sharon Yin Yee, Soh, Shui Yen, Loh, Amos Hong Pheng, Ngeow, Joanne
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Medicine; Cancer Genetics; Paediatric Cancer
• Online Access: https://hdl.handle.net/10356/136846
• Institution: Nanyang Technological University

Assessment of cancer predisposition syndromes (CPS) in childhood tumours is challenging to paediatric oncologists due to inconsistent recognizable clinical phenotypes and family histories, especially in cohorts with unknown prevalence of germline mutations. Screening checklists were developed to fac...