Fabrication of a biodegradable scaffold with localized response to bacterial infections

• Main Authors: Hassanbhai, Ammar M., Lim, Jing, Wen, Feng, Chee, Heng Li, Ho, Bow, Chong, Mark S.K., Teoh, Swee Hin
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Engineering::Chemical engineering; Polycaprolactone; Cryomilling
• Online Access: https://hdl.handle.net/10356/136870
• Institution: Nanyang Technological University

Implant-associated infections remain a significant source of morbidity in the clinic. Systemic administration of antibiotics is often ineffective, due in part to limited vascularization of the implant site. Here, we describe a physical method of incorporating antibiotics into biodegradable scaffolds...