Incorporating modified bases and base-backbone linkers into PNAs for targeting RNA secondary structures

• Main Author: Ong, Alan Ann Lerk
• Other Authors: Chen Gang
• Format: Thesis-Doctor of Philosophy
• Language: English
• Published: Nanyang Technological University 2020
• Subjects: Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/136984
• Institution: Nanyang Technological University

The structure diversity of RNA allows RNA to be involved in various biological processes. RNA secondary structures include the single-stranded (ss) loops and double-stranded (ds) stems and are involved in protein binding and gene regulation. Peptide nucleic acid (PNA) is a synthetic analog of DNA an...