A new therapeutic avenue for bronchiectasis : dry powder inhaler of ciprofloxacin nanoplex exhibits superior ex vivo mucus permeability and antibacterial efficacy to its native ciprofloxacin counterpart
Non-cystic fibrosis bronchiectasis (NCFB) characterized by permanent bronchial dilatation and recurrent infections has been clinically managed by long-term intermittent inhaled antibiotic therapy among other treatments. Herein we investigated dry powder inhaler (DPI) formulation of ciprofloxacin (CI...
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Main Authors: | Tran, The-Thien, Vidaillac, Celine, Yu, Hong, Yong, Valerie Fei Lee, Roizman, Dan, Chandrasekaran, Ravishankar, Lim, Albert Yick Hou, Low, Teck Boon, Tan, Gan Liang, Abisheganaden, John A., Koh, Mariko Siyue, Teo, Jeanette, Chotirmall, Sanjay Haresh, Hadinoto, Kunn |
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Other Authors: | School of Chemical and Biomedical Engineering |
Format: | Article |
Language: | English |
Published: |
2020
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/137077 |
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Institution: | Nanyang Technological University |
Language: | English |
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