Interaction analyses of 14-3-3ζ, Dok1, and phosphorylated integrin β cytoplasmic tails reveal a bi-molecular switch in integrin regulation

• Main Authors: Chatterjee, Deepak, D'Souza, Areetha, Zhang, Yaming, Bin, Wu, Tan, Suet-Mien, Bhattacharjya, Surajit
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Integrins; NMR
• Online Access: https://hdl.handle.net/10356/137105
• Institution: Nanyang Technological University

Integrins are hetero-dimeric (α and β subunits) type I transmembrane proteins that facilitate cell adhesion and migration. The cytoplasmic tails (CTs) of integrins interact with a plethora of intra-cellular proteins that are required for integrin bidirectional signaling. In particular, the β CTs of...