Autophagy governs protumorigenic effects of mitotic slippage-induced senescence

• Main Authors: Jakhar, Rekha, Luijten, Monique N. H., Wong, Alex X. F., Cheng, Bing, Guo, Ke, Neo, Suat P., Au, Bijin, Kulkarni, Madhura, Lim, Kah J., Maimaiti, Jiamila, Chong, Han Chung, Lim, Elaine H., Tan, Tee B. K., Ong, Kong W., Sim, Yirong, Wong, Jill S. L., Khoo, James B. K., Ho, Juliana T. S., Chua, Boon T., Sinha, Indrajit, Wang, Xiaomeng, Connolly, John E., Gunaratne, Jayantha, Crasta, Karen Carmelina
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Medicine; Chemotherapeutic; Tumor Progression
• Online Access: https://hdl.handle.net/10356/137179
• Institution: Nanyang Technological University

The most commonly utilized class of chemotherapeutic agents administered as a first-line therapy are antimitotic drugs; however, their clinical success is often impeded by chemoresistance and disease relapse. Hence, a better understanding of the cellular pathways underlying escape from cell death is...