A dual-function antibiotic-transporter conjugate exhibits superior activity in sterilizing MRSA biofilms and killing persister cells

A dual-function antibiotic-transporter conjugate exhibits superior activity in sterilizing MRSA biofilms and killing persister cells

New strategies are urgently needed to target MRSA, a major global health problem and the leading cause of mortality from antibiotic-resistant infections in many countries. Here, we report a general approach to this problem exemplified by the design and synthesis of a vancomycin-d-octaarginine conjug...

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Bibliographic Details
Main Authors: Antonoplis, Alexandra, Zang, Xiaoyu, Huttner, Melanie A., Chong, Kelvin Kian Long, Lee, Yu B., Co, Julia Y., Amieva, Manuel R., Kline, Kimberly A., Wender, Paul A., Cegelski, Lynette
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2020
Subjects:
Science::Biological sciences
Biofilms
Antimicrobial Agents
Online Access:https://hdl.handle.net/10356/137198
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/137198

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