Inhibiting S100B(ββ) for activating wild-type p53 : design of stapled peptides

• Main Authors: Kannan, Srinivasaraghavan, Aronica, Pietro G. A., Tan, Yaw Sing, Verma, Chandra Shekhar
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; S100B Protein; Cancer
• Online Access: https://hdl.handle.net/10356/137422
• Institution: Nanyang Technological University

S100B(ββ) is a member of the S100B protein family and is distributed in a cell-specific manner. Its levels are elevated in several cancers such as malignant melanoma and correlate directly with poor prognosis in patients. S100B(ββ) directly interacts with the tumor suppressor p53, inhibiting tetrame...