Gold and carbene relay catalytic enantioselective cycloisomerization/cyclization reactions of ynamides and enals

• Main Authors: Zhou, Liejin, Wu, Xingxing, Yang, Xing, Mou, Chengli, Song, Runjiang, Yu, Shuyan, Chai, Huifang, Pan, Lutai, Jin, Zhichao, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Chemistry::Organic chemistry; Bicyclic Lactams; Gold Catalyst
• Online Access: https://hdl.handle.net/10356/137569
• Institution: Nanyang Technological University

The combined use of gold as transition metal catalyst and N-heterocyclic carbene (NHC) as organic catalyst in the same solution for relay catalytic reactions was disclosed. The ynamide substrate was activated by gold catalyst to form unsaturated ketimine intermediate that subsequently reacted with t...