Access to cyclic β-amino acids by amine-catalyzed enantioselective addition of the γ-carbon atoms of α,β-unsaturated imines to enals

• Main Authors: Luo, Guoyong, Huang, Zhijian, Zhuo, Shitian, Mou, Chengli, Wu, Jian, Jin, Zhichao, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Chemistry::Organic chemistry; Amine Catalysis; Cyclic β-Amino Acid
• Online Access: https://hdl.handle.net/10356/137752
• Institution: Nanyang Technological University

Disclosed herein is a new catalytic approach for an efficient access to cyclic β-amino acids widely found in bioactive small molecules and peptidic foldamers. Our method involves addition of the remote γ-carbon atoms of α,β-unsaturated imines to enals by iminium organic catalysis. This highly chemo-...