Asymmetric synthesis of planar chiral carbonitriles and amines via carbene-catalyzed kinetic resolution

• Main Authors: Lv, Ya, Mou, Chengli, Liu, Qian, Shu, Liangzhen, Cai, Yuanlin, Lv, Xiaokang, Jin, Zhichao, Chi, Robin Yonggui
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2024
• Subjects: Chemistry; Amine; Carbene
• Online Access: https://hdl.handle.net/10356/174360
• Institution: Nanyang Technological University

We have developed a catalytic method using chiral N-heterocyclic carbene (NHC) as the sole organic catalyst to synthesize planar chiral carbonitriles asymmetrically, resulting in optically pure, multifunctional compounds. The method demonstrates remarkable tolerance toward diverse substituents and s...