Enantioselective indole N-H functionalization enabled by addition of carbene catalyst to indole aldehyde at remote site

• Main Authors: Yang, Xing, Luo, Guoyong, Zhou, Liejin, Liu, Bin, Zhang, Xiaolei, Gao, Hui, Jin, Zhichao, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Chemistry::Organic chemistry; N-Heterocyclic Carbene; N−H Functionalization
• Online Access: https://hdl.handle.net/10356/137779
• Institution: Nanyang Technological University

An enantioselective functionalization of the indole NH group is developed. The reaction stereoselectivity is controlled by an N-heterocyclic carbene catalyst that adds to an aldehyde moiety at the C7-carbon of indole. The NH group participating in the carbene-catalyzed reaction is part of the hetero...