N-Heterocyclic carbene-catalyzed remote enantioselective C-C bond formation via 1,6-addition with formyl enynes

• Main Authors: Peng, Xiaolin, Huang, Yixian, Wang, Wei, Li, Shiguang, Hao, Gefei, Ren, Shichao, Chi, Robin Yonggui
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2024
• Subjects: Chemistry; N-heterocyclic carbene; Organocatalysis
• Online Access: https://hdl.handle.net/10356/174245
• Institution: Nanyang Technological University

N-Heterocyclic carbenes (NHCs) have emerged as powerful organocatalysts in controlling the stereoselectivities of the reaction sites that are remote from the catalyst-binding position. Meanwhile, the construction of a stereogenic center at the δ-position through NHC catalysis remains an unmet goal....