Construction of tetrasubstituted silicon-stereogenic silanes via conformational isomerization and N‑heterocyclic carbenecatalyzed desymmetrization

• Main Authors: Zhou, Mali, Liu, Jianjian, Deng, Rui, Wang, Qingyun, Wu, Shuquan, Zheng, Pengcheng, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry; N-Heterocyclic Carbene; Organocatalysis
• Online Access: https://hdl.handle.net/10356/161337
• Institution: Nanyang Technological University

Disclosed here is a catalytic strategy for asymmetric access to chiral tetrasubstituted silicon-stereogenic silanes. Our reaction starts with a (covalently) symmetric silane bearing two aldehyde moieties as the substrate. Single-crystal structural analysis shows that the substrate exists as a racema...