Enantio- and diastereoselective synthesis of chromeno[4,3-b]pyrrole derivatives bearing tetrasubstituted chirality centers through carbene catalyzed cascade reactions

• Main Authors: Li, Tingting, Wang, Jilan, Xu, Jun, Jin, Jiamiao, Chi, Robin Yonggui, Jin, Zhichao
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Chemistry::Organic chemistry; Chirality; N-Hetereocyclic Carbene
• Online Access: https://hdl.handle.net/10356/137900
• Institution: Nanyang Technological University

An NHC-catalyzed cascade cycloaddition reaction is developed for quick access to structurally sophisticated tetrahydrochromeno[4,3-b]pyrrole derivatives. A sterically congested tetrasubstituted chirality carbon center is formed during the cyclization process. All the α-, β-, and carbonyl carbons of...