Digital karyotyping of cancer cell lines from NGS data

• Main Author: Ahmed Ibrahim Samir Khalil
• Other Authors: Anupam Chattopadhyay
• Format: Thesis-Doctor of Philosophy
• Language: English
• Published: Nanyang Technological University 2020
• Subjects: Engineering::Computer science and engineering::Mathematics of computing::Mathematical software; Engineering::Computer science and engineering::Mathematics of computing::Probability and statistics
• Online Access: https://hdl.handle.net/10356/138176
• Institution: Nanyang Technological University

Human immortalized and transformed cell lines are the workhorse of cancer research. They are widely used to study cancer biology and to test and screen anti-cancer compounds in order to improve the efficacy of cancer treatment. Detection of DNA copy number alterations (CNAs) is critical to understan...