Enantioselective access to multi-cyclic α-amino phosphonates via carbene-catalyzed cycloaddition reactions between enals and six-membered cyclic imines

• Main Authors: Sun, Jun, Mou, Chengli, Liu, Changyi, Huang, Ruoyan, Zhang, Shupeng, Zheng, Pengcheng, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Chemistry::Organic chemistry; Amino Phosphonate; Ketiminophosphonates
• Online Access: https://hdl.handle.net/10356/138239
• Institution: Nanyang Technological University

A carbene-catalyzed enantioselective cycloaddition reaction between enals and cyclic ketiminophosphonates is disclosed. α-Amino phosphonates bearing sophisticated fused heterocycles and quaternary carbons are afforded with excellent enantioselectivities. The α-amino phosphonate products from our app...