Atherogenesis and plaque rupture, surface/interface-related phenomena

• Main Authors: Siegel, G., Berkholz, J., Klüßendorf, D., Knosalla, C., Zakrzewicz, A., Ermilov, E., Malmsten, M., Lindman, Bjorn
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Engineering::Materials; Atherogenesis And Plaque Rupture; Oxidized Low-density Lipoprotein
• Online Access: https://hdl.handle.net/10356/138392
• Institution: Nanyang Technological University

In atherogenesis, free oxygen radicals cause a lipid peroxidation of apoB100-containing lipoproteins in the blood, at the blood–endothelium-interface and in the subendothelial space. These lipoproteins easily aggregate, bind to their receptor heparan sulfate proteoglycan and calcify to arteriosclero...