Re-understanding the mechanisms of action of the anti-mycobacterial drug bedaquiline

• Main Authors: Sarathy, Jickky Palmae, Gruber, Gerhard, Dick, Thomas
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences::Biochemistry; Science::Biological sciences::Molecular biology; Tuberculosis; Bedaquiline
• Online Access: https://hdl.handle.net/10356/138546
• Institution: Nanyang Technological University

Bedaquiline (BDQ) inhibits ATP generation in Mycobacterium tuberculosis by interfering with the F-ATP synthase activity. Two mechanisms of action of BDQ are broadly accepted. A direct mechanism involves BDQ binding to the enzyme’s c-ring to block its rotation, thus inhibiting ATP synthesis in the en...