Re-understanding the mechanisms of action of the anti-mycobacterial drug bedaquiline
Bedaquiline (BDQ) inhibits ATP generation in Mycobacterium tuberculosis by interfering with the F-ATP synthase activity. Two mechanisms of action of BDQ are broadly accepted. A direct mechanism involves BDQ binding to the enzyme’s c-ring to block its rotation, thus inhibiting ATP synthesis in the en...
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Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
2020
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Online Access: | https://hdl.handle.net/10356/138546 |
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Institution: | Nanyang Technological University |
Language: | English |