Catalytic asymmetric conjugate arylation of γ,δ-unsaturated β-dicarbonyl compounds
The first catalytic asymmetric conjugate addition to γ,δ-unsaturated β-dicarbonyl compounds was developed. With a chiral diene-rhodium(I) μ-chloro dimer as the catalyst in toluene/H2O, asymmetric conjugate arylation of γ,δ-unsaturated β-dicarbonyl compounds with arylboronic acids proceeded in high e...
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sg-ntu-dr.10356-1387392020-05-12T05:49:37Z Catalytic asymmetric conjugate arylation of γ,δ-unsaturated β-dicarbonyl compounds Yao, Jian Yin, Long Shen, Yue Lu, Tao Hayashi, Tamio Dou, Xiaowei School of Physical and Mathematical Sciences Science::Chemistry Catalysts Hydrocarbons The first catalytic asymmetric conjugate addition to γ,δ-unsaturated β-dicarbonyl compounds was developed. With a chiral diene-rhodium(I) μ-chloro dimer as the catalyst in toluene/H2O, asymmetric conjugate arylation of γ,δ-unsaturated β-dicarbonyl compounds with arylboronic acids proceeded in high efficiency with excellent enantioselectivities. The generated β-dicarbonyl products are versatile chiral synthons, which can be easily converted to diverse important chiral structures. MOE (Min. of Education, S’pore) 2020-05-12T05:49:36Z 2020-05-12T05:49:36Z 2018 Journal Article Yao, J., Yin, L., Shen, Y., Lu, T., Hayashi, T., & Dou, X. (2018). Catalytic asymmetric conjugate arylation of γ,δ-unsaturated β-dicarbonyl compounds. Organic Letters, 20(21), 6882-6885. doi:10.1021/acs.orglett.8b03021 1523-7060 https://hdl.handle.net/10356/138739 10.1021/acs.orglett.8b03021 30350648 2-s2.0-85054901510 21 20 6882 6885 en Organic Letters © 2018 American Chemical Society. All rights reserved. |
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Science::Chemistry Catalysts Hydrocarbons |
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Science::Chemistry Catalysts Hydrocarbons Yao, Jian Yin, Long Shen, Yue Lu, Tao Hayashi, Tamio Dou, Xiaowei Catalytic asymmetric conjugate arylation of γ,δ-unsaturated β-dicarbonyl compounds |
| description |
The first catalytic asymmetric conjugate addition to γ,δ-unsaturated β-dicarbonyl compounds was developed. With a chiral diene-rhodium(I) μ-chloro dimer as the catalyst in toluene/H2O, asymmetric conjugate arylation of γ,δ-unsaturated β-dicarbonyl compounds with arylboronic acids proceeded in high efficiency with excellent enantioselectivities. The generated β-dicarbonyl products are versatile chiral synthons, which can be easily converted to diverse important chiral structures. |
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School of Physical and Mathematical Sciences |
| author_facet |
School of Physical and Mathematical Sciences Yao, Jian Yin, Long Shen, Yue Lu, Tao Hayashi, Tamio Dou, Xiaowei |
| format |
Article |
| author |
Yao, Jian Yin, Long Shen, Yue Lu, Tao Hayashi, Tamio Dou, Xiaowei |
| author_sort |
Yao, Jian |
| title |
Catalytic asymmetric conjugate arylation of γ,δ-unsaturated β-dicarbonyl compounds |
| title_short |
Catalytic asymmetric conjugate arylation of γ,δ-unsaturated β-dicarbonyl compounds |
| title_full |
Catalytic asymmetric conjugate arylation of γ,δ-unsaturated β-dicarbonyl compounds |
| title_fullStr |
Catalytic asymmetric conjugate arylation of γ,δ-unsaturated β-dicarbonyl compounds |
| title_full_unstemmed |
Catalytic asymmetric conjugate arylation of γ,δ-unsaturated β-dicarbonyl compounds |
| title_sort |
catalytic asymmetric conjugate arylation of γ,δ-unsaturated β-dicarbonyl compounds |
| publishDate |
2020 |
| url |
https://hdl.handle.net/10356/138739 |
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1681059790433812480 |