Therapeutic treatment of Zika virus infection using a brain-penetrating antiviral peptide

• Main Authors: Jackman, Joshua A., Costa, Vivian V., Park, Soohyun, Real, Ana Luiza Campos Vila, Park, Jae Hyeon, Cardozo, Pablo L., Abdul Rahim Ferhan, Olmo, Isabella G., Moreira, Thaiane P., Bambirra, Jordana L., Queiroz, Victoria F., Queiroz-Junior, Celso M., Foureaux, Giselle, Souza, Danielle G., Ribeiro, Fabiola M., Yoon, Bo Kyeong, Wynendaele, Evelien, Spiegeleer, Bart De, Teixeira, Mauro M., Cho, Nam-Joon
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Medicine; Antiviral Agents; Drug Development
• Online Access: https://hdl.handle.net/10356/138822
• Institution: Nanyang Technological University

Zika virus is a mosquito-borne virus that is associated with neurodegenerative diseases, including Guillain-Barré syndrome1 and congenital Zika syndrome2. As Zika virus targets the nervous system, there is an urgent need to develop therapeutic strategies that inhibit Zika virus infection in the brai...