Parallel alignment of bacteria using near-field optical force array for cell sorting

Parallel alignment of bacteria using near-field optical force array for cell sorting

This paper presents a near-field approach to align multiple rod-shaped bacteria based on the interference pattern in silicon nano-waveguide arrays. The bacteria in the optical field will be first trapped by the gradient force and then rotated by the scattering force to the equilibrium position. In t...

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Bibliographic Details
Main Authors: Zhao, Hai Tao, Zhang, Yi, Chin, Lip Ket, Yap, Peng Huat, Wang, K., Ser, Wee, Liu, Ai Qun
Other Authors: School of Electrical and Electronic Engineering
Format: Conference or Workshop Item
Language:English
Published: 2020
Subjects:
Engineering::Electrical and electronic engineering::Optics, optoelectronics, photonics
Rod-shaped Bacteria
Near-field
Online Access:https://hdl.handle.net/10356/138926
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Institution: Nanyang Technological University
Language: English
Description
Summary:This paper presents a near-field approach to align multiple rod-shaped bacteria based on the interference pattern in silicon nano-waveguide arrays. The bacteria in the optical field will be first trapped by the gradient force and then rotated by the scattering force to the equilibrium position. In the experiment, the Shigella bacteria is rotated 90 deg and aligned to horizontal direction in 9.4 s. Meanwhile, ~150 Shigella is trapped on the surface in 5 min and 86% is aligned with angle < 5 deg. This method is a promising toolbox for the research of parallel single-cell biophysical characterization, cell-cell interaction, etc.

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