Cobalt-catalyzed directed : ortho-methylation of arenes with methyl tosylate

• المؤلفون الرئيسيون: Sun, Qiao, Yoshikai, Naohiko
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2020
• الموضوعات: Science::Chemistry; Methyl Tosylate; Ortho-methylation
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/139028
• المؤسسة: Nanyang Technological University

A cobalt-catalyzed directed ortho C-H methylation reaction of arenes has been achieved using readily available methyl tosylate as a methylating agent. An in situ-generated cobalt-N-heterocyclic carbene catalyst in combination with neopentylmagnesium bromide promotes the methylation at room temperatu...