Genetic discrimination between LADA and childhood-onset type 1 diabetes within the MHC

• Main Authors: Mishra, Rajashree, Åkerlund, Mikael, Cousminer, Diana L., Ahlqvist, Emma, Bradfield, Jonathan P., Chesi, Alessandra, Hodge, Kenyaita M., Guy, Vanessa C., Brillon, David J., Pratley, Richard E., Rickels, Michael R., Vella, Adrian, Ovalle, Fernando, Harris, Ronald I., Melander, Olle, Varvel, Stephen, Hakonarson, Hakon, Froguel, Phillippe, Lonsdale, John T., Mauricio, Didac, Schloot, Nanette C., Khunti, Kamlesh, Greenbaum, Carla J., Yderstræde, Knud B., Tuomi, Tiinamaija, Voight, Benjamin F., Schwartz, Stanley, Boehm, Bernhard Otto, Groop, Leif, Leslie, Richard David, Grant, Struan F. A.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Medicine; Type 1 Diabetes; MHC
• Online Access: https://hdl.handle.net/10356/139103
• Institution: Nanyang Technological University

The MHC region harbors the strongest loci for latent autoimmune diabetes in adults (LADA); however, the strength of association is likely attenuated compared with that for childhood-onset type 1 diabetes. In this study, we recapitulate independent effects in the MHC class I region in a population with type 1 diabetes and then determine whether such conditioning in LADA yields potential genetic discriminators between the two subtypes within this region.