Metabolomics reveals that dietary xenoestrogens alter cellular metabolism induced by palbociclib/letrozole combination cancer therapy

Metabolomics reveals that dietary xenoestrogens alter cellular metabolism induced by palbociclib/letrozole combination cancer therapy

Recently, the palbociclib/letrozole combination therapy was granted accelerated US FDA approval for the treatment of estrogen receptor (ER)-positive breast cancer. Since the underlying metabolic effects of these drugs are yet unknown, we investigated their synergism at the metabolome level in MCF-7...

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Bibliographic Details
Main Authors: Warth, Benedikt, Raffeiner, Philipp, Granados, Ana, Huan, Tao, Fang, Mingliang, Forsberg, Erica M., Benton, H. Paul, Goetz, Laura, Johnson, Caroline H., Siuzdak, Gary
Other Authors: School of Civil and Environmental Engineering
Format: Article
Language:English
Published: 2020
Subjects:
Science::Biological sciences
Combinatory Chemotherapy
Ibrance
Online Access:https://hdl.handle.net/10356/139116
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/139116

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