Structure and function of Mycobacterium-specific components of F-ATP synthase subunits α and ε

• Main Authors: Bogdanović, Nebojša, Sundararaman, Lavanya, Kamariah, Neelagandan, Tyagi, Anu, Bhushan, Shashi, Ragunathan, Priya, Shin, Joon, Dick, Thomas, Grüber, Gerhard
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences::Biochemistry; Science::Biological sciences::Molecular biology; Mycobacterium; F-ATP Synthase
• Online Access: https://hdl.handle.net/10356/139277
• Institution: Nanyang Technological University

The Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase (α3:β3:γ:δ:ε:a:b:b’:c9) is an essential enzyme that supplies energy for both the aerobic growing and the hypoxic dormant stage of the mycobacterial life cycle. Employing the heterologous F-ATP synthase model system αchi3:β3:γ we showed previousl...