Enriched expression of neutral sphingomyelinase 2 in the striatum is essential for regulation of lipid raft content and motor coordination

• Main Authors: Tan, Laura Hui-Ru, Tan, Angela Jin-Rong, Ng, Yu-Ying, Chua, John Jia-En, Chew, Wee-Siong, Muralidharan, Sneha, Torta, Federico, Dutta, Bamaprasad, Sze, Siu Kwan, Herr, Deron R., Ong, Wei-Yi
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; nSMase2; Motor Function
• Online Access: https://hdl.handle.net/10356/139285
• Institution: Nanyang Technological University

Sphingomyelinases are a family of enzymes that hydrolyze sphingomyelin to generate phosphocholine and ceramide. The brain distribution and function of neutral sphingomyelinase 2 (nSMase2) were elucidated in this study. nSMase2 mRNA expression was greatest in the striatum, followed by the prefrontal...